The Systems Biology of Aging Group was founded by Dr. Robi Tacutu in 2016, and is part of the department of Bioinformatics and Structural Biochemistry at the Institute of Biochemistry of the Romanian Academy. The group is currently funded by a recently awarded EUR 1.9 million grant (Romanian/EU co-funded) for the project “Multi-omics Prediction System for Prioritization of Gerontological Interventions”.
The main areas of interest in the group include studying biology of ageing/biogerontology, systems biology and bioinformatics, overall the expertise required to acheive these spanning multiple research fields (from bioinformatics to synthetic biology).
With a highly multi-disciplinary team, the projects tackeled by the group include both computational aspects (data aggregation and processing, multi-dimensional data analysis, network-based methods, systems theory approaches, deep learning, etc.) as well as wet-lab experiments (in particular in-vivo testing of the computationally predicted interventions).
Human Ageing Genomic Resources: new and updated databases., Nucleic acids research, 46(D1), D1083-D1090, 2018
Tacutu R, Thornton D, Johnson E, Budovsky A, Barardo D, Craig T, Diana E, Lehmann G, Toren D, Wang J, Fraifeld VE, de Magalhães JP
IF = 11.56
Wide-scale comparative analysis of longevity genes and interventions., Aging cell, 16(6), 1267-1275, 2017
Yanai H, Budovsky A, Barzilay T, Tacutu R, Fraifeld VE
Hydrogen sulfide enhances pancreatic β-cell differentiation from human tooth under normal and glucotoxic conditions., Regenerative Medicine, 2(12), 125-141, 2017
Matei IV, Ii H, Yaegaki K
MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity., Nucleic Acids Res.(44), D1262–D1265, 2015
Toren D, Barzilay T, Tacutu R, Lehmann G, Muradian KK, Fraifeld VE.
Contributions of evolutionary biology to the understanding of cancer., Proceedings of the Romanian Academy Series B, 3(14), 183-190, 2012
Ionescu-Tirgoviste C, Matei IV, Ivanus B, Falcan AM.
Correlations of visfatin with the lipidic metabolism in diabetic and obese patients., Proceedings of the Romanian Academy Series B, 1(14), 37-43, 2012
Gligor R, Zdremtan D, Pilat L, Matei I, Ionescu-Tirgoviste C, Crisnic I.
A cytomorphometric analysis of adipocytes from the omental and abdominal subcutaneous adipose tissue, Proceedings of the Romanian Academy Series B, 3(13), 212-236, 2011
Ionescu-Tirgoviste C, Matei IV, Gubceac E, Militaru M, Gutu D, Lixandru D.
MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?, Rejuvenation research, 13(2-3), 373-7, 2010
Tacutu R, Budovsky A, Wolfson M, Fraifeld VE
Gerontomics: Multi-omics prediction system for prioritization of gerontological interventions
Project director: Robi Tacutu
Anton Yurievich Kulaga,
Ioan Valentin Matei,
Starting 02.09.2016, the Institute of Biochemistry of the Romanian Academy is implementing the project “Multi-omics prediction system for prioritization of gerontological interventions”, co-funded through European Fund for Regional Development, in accordance with the funding contract signed by the Ministry of National Education and Scientific Research. The total funding for the project is 8.524.757,50 lei, of which 8.502.557,50 lei represent non-reimbursable funding. The project’s duration is 48 months.
Microsoft Azure Research sponsorship
Acronym: ML for Aging Research
Project director: Robi Tacutu