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Grants

Type
Next Generation Viral Hepatitis B and C vaccine development in plants and algae using advanced biotechnological tools; ‘’Dezvoltare de vaccinuri de ultima generatie anti Virusurile Hepatice B si C in plante si alge, utilizand metode biotehnologice avansate’’
europe EU co-funded 2019-2023
Acronym: SmartVac
Project director: Norica Nichita

We aim to produce high yields of novel HBV/HCV antigens with superior immunogenic properties in plants and mammalian cells, based on innovative molecular design and establish in premiere an advanced biotechnological platform for production of best vaccine candidates antigens in algae.

Gerontomics: Multi-omics prediction system for prioritization of gerontological interventions
europe EU co-funded 2016-2021
Acronym: Gerontomics
Project director: Robi Tacutu

Starting 02.09.2016, the Institute of Biochemistry of the Romanian Academy is implementing the project “Multi-omics prediction system for prioritization of gerontological interventions”, co-funded through European Fund for Regional Development, in accordance with the funding contract signed by the Ministry of National Education and Scientific Research. The total funding for the project is 8.524.757,50 lei, of which 8.502.557,50 lei represent non-reimbursable funding. The project’s duration is 48 months.

Development of a cost effective Romania-Norway joint plant-based technology platform for production of vaccines against Human Hepatitis viruses B (HBV) and C (HCV)
europe EU co-funded 2014-2017
Acronym: GREENVAC
Project director: Norica Nichita

Hepatitis B (HBV) and C viruses (HCV) are important human pathogens resulting in more than 500 million people being currently carriers. Sadly, Romania has the highest prevalence of HBV/HCV infections among the EU countries (up to 7% of the population). Chronically infected patients of HBV and HCV are at high risk to develop severe liver diseases, such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).

Biotehnologii Celulare si Moleculare cu Aplicatii in Medicina
europe EU co-funded 2010-2013
Acronym: Programul Postdoctoral
Project director: Stefana-Maria Petrescu

Programul Postdoctoral "Biotehnologii Celulare si Moleculare cu Aplicatii in Medicina", se adreseaza tinerilor cu diploma de doctor in biologie, chimie, fizica, medicina si informatica - interesati de burse de cercetare Post Doctorala la standarde europene.

Dezvoltarea infrastructurii de cercetare a Institutului de Biochimie in vederea cresterii competitivitatii in domeniul proteomicii biomedicale
europe EU co-funded 2010-2012
Acronym: PROCERA
Project director: Stefana-Maria Petrescu

Scopul PROCERA este de a dezvolta infrastructura IBAR pentru cresterea capacitatii de cercetare-dezvoltare C-D in domeniul biochimiei si biologiei moleculare pe plan national, precum si a competitivitatii cercetarii stiintifice romanesti la nivel european.

Intarirea capacitatii administrative a Institutului de Biochimie
europe EU co-funded 2010
Acronym: ICAIB
Project director: Anca Roseanu

Începând cu data de 16.06.2010, Institutul de Biochimie beneficiază de asistenţă financiară nerambursabilă pentru implementarea proiectului “Întărirea capacităţii administrative”, în baza contractului de finanţare nr. 167/16.06.2010 semnat cu Organismul Intermediar ANCS Bucureşti.

Microfluidic assay of FGF2 therapeutic administration for bone regeneration
romania National 2017-2019
Acronym: μFGF2bone
Project director: Gabriela Chiritoiu

Musculoskeletal disorders affect 1 in 7 people and fractures alone affect 1 in 50 people annually while 10% of bone injuries fail to heal. Our present proposal aims to test for the first time the potential of fibroblast growth factor-2 (FGF2), to be administered as a stimulatory drug to enhance bone regeneration.

In vitro evaluation of potential biomedical strategies aimed to prevent bone loss during spaceflight
romania National 2017-2019
Acronym: SPACEBONE
Project director: Stefana-Maria Petrescu

Bone loss represents one of the most important health problems experienced by Space travelling astronauts. Microgravity produces deterioration of the skeleton due to lack of mechanical loading thus affecting both muscle and bones. Tendons stiffness decreases, muscle fibres atrophies and attenuates their metabolic capacity, whileprogressive cartilage loss occurs.

Structure Assisted Investigation of Critical Protein Families Involved in Plant Immunity
romania National 2017-2019
Acronym: STRASSIST
Project director: Andrei-José Petrescu

This project aims to address a number of structural aspects related to key elements of the plant immune system and its pathogen interactors using a combined approach intricating experimental and computational steps. To this end we intend to build on our previous results in the field and further develop experimental, bioinformatics and molecular modeling methods appropriate for solving the specific problems implied by this proposal.

Development of a fluorescence-based technology to screen for RAGE-ligand binding inhibitors
romania National 2016-2020
Acronym: FLUORORAGE
Project director: Ioana Popa

The receptor for advanced glycation end-products (RAGE) and its ligands are important players in pathological conditions such as diabetes, neurodegenerative diseases, and cancers. RAGE is a cell surface molecule of the immunoglobulin superfamily. Alternatively spliced variants lacking either only the intracellular domain or both the intracellular and the transmembrane domains are also expressed in some tissues.

Platforma robusta pentru descoperirea de medicamente anti-diabetice
romania National 2016-2019
Acronym: PLATFORMDIAB
Project director: Florentina Pena

Societatea contemporana se afla in mijlocul unei epidemii globale de diabet zaharat tip 2. Aceasta boala este caracterizata de concentratii patologic crescute de glucoza in sangele pacientilor datorita productiei, secretiei si utilizarii inadecvate a insulinei - hormonul principal care regleaza concentratia de glucoza serica. Ne propunem sa generam linii reporter stabile ce pot fi utilizate pentru cuantificarea insulinei secretate.

Identification of host factors involved in hepatitis C virus assembly and characterization of their potential role in vivo
romania National 2014
Acronym: HCVASSEMBLY
Project director: Costin-Ioan Popescu

Hepatitis C virus (HCV) is an important human pathogen that infects the liver and establishes chronic infection in the majority of cases, leading to cirrhosis and hepatocellular carcinoma over the course of many years. Despite recent progress, details of the HCV life cycle are still missing, with the HCV assembly process being particularly poorly understood.

Selectia cailor de degradare a proteinelor in patogeneza bolilor umane
romania National 2013-2015
Acronym: PRODEGRAD
Project director: Stefana-Maria Petrescu

A considerable fraction of all newly synthesized secretory polypeptides fail to attain their native conformation due to mutations, transcriptional and translational errors, folding defects or endoplasmic reticulum (ER) stress conditions.

Role of the ERAD pathway in the degradation of tyrosinase and production of antigenic peptides in human melanoma
romania National 2012-2015
Acronym: TYRPRES
Project director: Stefana-Maria Petrescu

A detailed knowledge of the mechanisms of antigen processing and presentation is essential to optimize cancer vaccination. known as Endoplasmic Reticulum Associated Degradation (ERAD). Non cytosolic misfolded proteins, synthesized at the endoplasmic reticulum are degraded to peptides by a complex machinery Cancer immunotherapy aims at harnessing the resources of the immune system to treat cancer.

Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma
romania National 02/05/2018 - 30/04/2020
Acronym: IMUNOPEP
Project director: Cristian Munteanu

A promising approach of the therapeutic strategy in melanoma is immunotherapy. One of the most promising melanoma antigens is tyrosinase, which was frequently found as overexpressed in melanomas. It wash shown that this protein undergoes unproductive folding in the endoplasmic reticulum (ER) leading to the selection of the incorrectly folded molecules for degradation via the ubiquitin proteasome system. The current project aims to obtain epitopes with potential increased clinical outcome.

Microsoft Azure Research
sponsorship Sponsorship 2017-2018
Acronym: ML for Aging Research
Project director: Robi Tacutu

The Systems Biology of Aging team is grateful for the "Microsoft Azure for Research" sponsorship awarded to our group. We have received cloud computing resources worth the equivalent of 20,000$ credits, and this has greatly helped us to speed up some of our research projects.