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Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma

Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma 02/05/2018 - 30/04/2020
Acronym: IMUNOPEP
Project director: Cristian Munteanu
External website: full link

A promising approach of the therapeutic strategy in melanoma is immunotherapy. One of the most promising melanoma antigens is tyrosinase, which was frequently found as overexpressed in melanomas. It wash shown that this protein undergoes unproductive folding in the endoplasmic reticulum (ER) leading to the selection of the incorrectly folded molecules for degradation via the ubiquitin proteasome system. The current project aims to obtain epitopes with potential increased clinical outcome.

Cristian Munteanu, Dr.
Cristian Munteanu, Dr.

Research Scientist

ACADEMIC CAREER 2016 – present: Research Scientist (CS) at the Institute of Biochemistry of the Romanian Academy (IBRA) 2014 – 2016: Research Assistant at IBRA EDUCATION AND TRAINING 2011 – 2016: Ph.D. in Biology at Institute of Biochemistry of the Romanian Academy (IBRA) with the thesis title: “Insights into functional interaction proteomics of endoplasmic reticulum associated degradation (ERAD) and antigen presentation in melanoma using mass spectrometry”, Coordinators: Dr. Andrei Jose Petrescu/Dr. Niculina Mitrea (University of Medicine and Pharmacy Carol Davila, Bucharest) 2011 – 2014: Resident Pharmacist in Pharmaceutical Laboratory at Uni More...

Stefana-Maria Petrescu, Dr.
Stefana-Maria Petrescu, Dr.

Director of Institute, Head of Department

Dr. Petrescu graduated from the Department of Biochemistry, University of Bucharest and obtained a PhD in Biology from the Romanian Academy. She was a DAAD fellow and FEBS fellowship recipient at University of Wurzbur More...