Cristian Munteanu, Dr.

Cristian Munteanu

Research Scientist

Biography

ACADEMIC CAREER
2019: Research Scientist (CS) III at the Institute of Biochemistry of the Romanian Academy (IBRA)
2016 – 2019: Research Scientist (CS) at the Institute of Biochemistry of the Romanian Academy (IBRA)
2014 – 2016: Research Assistant at IBRA

EDUCATION AND TRAINING
2012 – 2017: Ph.D. in Biology at Institute of Biochemistry of the Romanian
Academy (IBRA) with the thesis title: “Insights into functional
interaction proteomics of endoplasmic reticulum associated
degradation (ERAD) and antigen presentation in melanoma using
mass spectrometry”, Coordinators: Dr. Andrei Jose Petrescu/Dr.
Niculina Mitrea (University of Medicine and Pharmacy Carol Davila,
Bucharest)
2011 – 2014: Resident Pharmacist in Pharmaceutical Laboratory at University of
Medicine and Pharmacy (UMF) Carol Davila, Bucharest, Romania
(Accredited Postgraduate Medical Specialization by the Ministry of
Health from Romania)
2010 – 2012: MSc in Biological Chemistry at Normal Superior School of
Bucharest (NSSB) - IBRA with the thesis title: “Expression and
purification of the antimicrobial peptide Cecropin P1 in Escherichia
Coli”
2005 – 2010: B.Sc. and M.Sc in Pharmacy at UMF Carol Davila (Bucharest,
Romania) with the thesis title: “HPLC and molecular modeling
stability evaluation of inclusion complexes between repaglinide and
beta-cyclodextrin”

Papers

Year
  • Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V A Munteanu, Valentina UivarosiAna-Madalina Maciuca et al . "A Study on Repositioning Nalidixic Acid via Lanthanide Complexation: Synthesis, Characterization, Cytotoxicity and DNA/Protein Binding Studies", Pharmaceuticals 18(15): 1010, (2022)
    IF: 5.20AI: 0.67
  • Roxana Ghiulai, Marius Mioc, Roxana Racoviceanu 2 3, Alexandra Prodea 2 3, Andreea Milan 2 3, Dorina Coricovac, Cristina Dehelean, Ștefana Avram, Alina D Zamfir, Cristian V A Munteanu, Viviana Ivan, Codruța ŞoicaRoxana Ghiulai et al . "Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry", Molecules 21(27): 7359, (2022)
    IF: 4.93AI: 0.67
  • Raluca Ica, Kristina Mlinac-Jerkovic, Katarina Ilic, Tomislav Sajko, Cristian V A Munteanu, Alina D Zamfir, Svjetlana Kalanj-BognarRaluca Ica et al . "Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry", Molecules 13(27): 4056, (2022)
    IF: 4.93AI: 0.67
  • Suteanu-Simulescu A, Zamfir AD, Ica R, Sarbu M, Munteanu CVA, Gadalean F, Vlad A, Bob F, Jianu DC, Petrica LSuteanu-Simulescu A et al . "High-Resolution Tandem Mass Spectrometry Identifies a Particular Ganglioside Pattern in Early Diabetic Kidney Disease of Type 2 Diabetes Mellitus Patients", Molecules (Basel, Switzerland) 27(9), (2022)
    IF: 4.93AI: 0.67
  • Iulia-Roxana Angelescu, Silvia-Simona Grosu-Tudor # 1, Lucia-Roxana Cojoc, Gabriel-Mihai Maria, Gabriela N Chirițoiu, Cristian V A Munteanu, Medana ZamfirIulia-Roxana Angelescu et al . "Isolation, characterization, and mode of action of a class III bacteriocin produced by Lactobacillus helveticus 34.9", World J Microbiol Biotechnol .(38): 220, (2022)
    IF: 4.25AI: 0.64
  • Szedlacsek HS, Bajusz D, Badea RA, Pop A, Bică CC, Ravasz L, Mittli D, Mátyás D, Necula-Petrăreanu G, Munteanu CVA, Papp I, Juhász G, Hritcu L, Keserű GM, Szedlacsek SE.Szedlacsek HS et al . "Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats", JOURNAL OF MEDICINAL CHEMISTRY 1520-4804(ISSN 0022-2623), (2021)
    IF: 7.45
  • Munteanu CVA, Chirițoiu GN, Chirițoiu M, Ghenea S, Petrescu AJ, Petrescu ȘMMunteanu CVA et al . "Affinity proteomics and deglycoproteomics uncover novel EDEM2 endogenous substrates and an integrative ERAD network", Molecular & cellular proteomics : MCP: 100125, (2021)
    IF: 5.91AI: 2.26
  • Patras L, Ionescu AE, Munteanu C, Hajdu R, Kosa A, Porfire A, Licarete E, Rauca VF, Sesarman A, Luput L, Bulzu P, Chiroi P, Tranca RA, Meszaros MS, Negrea G, Barbu-Tudoran L, Potara M, Szedlacsek S, Banciu MPatras L et al . "Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo", Cancer biology & therapy: 1-16, (2021)
    IF: 4.74
  • Manica G, Ghenea S, Munteanu CVA, Martin EC, Butnaru C, Surleac M, Chiritoiu GN, Alexandru PR, Petrescu AJ, Petrescu SMManica G et al . "EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning", Int. J. Mol. Sci. 4(22): 2172, (2021)
    IF: 4.56
  • Ica R, Munteanu CV, Vukelic Z, Zamfir ADIca R et al . "High-resolution mass spectrometry reveals a complex ganglioside pattern and novel polysialylated structures associated with the human motor cortex", European journal of mass spectrometry (Chichester, England): 14690667211040912, (2021)
    IF: 0.85
  • Chirițoiu GN, Chirițoiu M, Munteanu CVAChirițoiu GN et al . "Dataset of human EDEM2 melanoma cells proteomics, affinity proteomics and deglycoproteomics", Data in brief 39: 107471, (2021)
  • Gheorghe RO, Deftu A, Filippi A, Grosu A, Bica-Popi M, Chiritoiu M, Chiritoiu G, Munteanu C, Silvestro L, Ristoiu VGheorghe RO et al . "Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning", Cellular and molecular neurobiology, (2020)
    IF: 3.80
  • Ionescu AE, Mentel M, Munteanu CVA, Sima LE, Martin EC, Necula-Petrareanu G, Szedlacsek SEIonescu AE et al . "Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation", International Journal of Molecular Sciences 20(24): 6307, (2019)
    IF: 4.18
  • Sarbu M, Ica R, Petrut A, Vukelić Ž, Munteanu CVA, Petrescu AJ, Zamfir ADSarbu M et al . "Gangliosidome of human anencephaly: A high resolution multistage mass spectrometry study", Biochimie 163: 142-151, (2019)
    IF: 3.36
  • Tanase CI, Cocu F, Draghici C, Hanganu A, Pintilie L, Maganu M, Munteanu CVA, Shova STanase CI et al . "Secondary compounds in the catalytic hydrogenation of enone and allylic alcohol prostaglandin intermediates: isolation, characterization, and X-ray crystallography", New Journal of Chemistry 43(20): 7582-7599, (2019)
    IF: 3.00
  • Munteanu CVA, Chiritoiu GN, Petrescu AJ, Petrescu ȘMMunteanu CVA et al . "Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry", Advances in experimental medicine and biology 1140: 155-167, (2019)
    IF: 2.13
  • Sarbu M, Dehelean L, Munteanu CVA, Ica R, Petrescu AJ, Zamfir ADSarbu M et al . "Human caudate nucleus exhibits a highly complex ganglioside pattern as revealed by high-resolution multistage Orbitrap MS", Journal of Carbohydrate Chemistry 38(9), (2019)
    IF: 0.80
  • Sarbu M, Munteanu CV, Dehelean L, Petrescu AJ, Peter-Katalinic J, Zamfir AD.Sarbu M et al . "Identification and structural characterization of novel O- and N-glycoforms in the urine of a Schindler disease patient by Orbitrap mass spectrometry", Journal of Mass Spectrometry 50(9): 1044‐1056, (2015)
    IF: 2.54AI: 0.70
  • GABRIELA N. CHIRIȚOIU, CRISTIAN V.A. MUNTEANU, NICULINA MITREAGABRIELA N. CHIRIȚOIU et al . "COMBINING HETEROLOGOUS BACTERIAL EXPRESSION SYSTEM WITH AFFINITY CHROMATOGRAPHY PURIFICATION TO OBTAIN NATIVE MOUSE TYROSINASE", Farmacia 2(63): 254-261, (2015)
    IF: 1.16
  • Sela H, Spiridon LN, Ashkenazi H, Bhullar NK, Brunner S, Petrescu AJ, Fahima T, Keller B, Jordan T.Sela H et al . "Three-dimensional Modeling and Diversity Analysis Reveals Distinct AVR Recognition Sites and Evolutionary Pathways in Wild and Domesticated Wheat Pm3 R Genes", Molecular Plant Microbe Interactions 27(8): 835-845, (2014)
    IF: 3.94AI: 1.30
  • Flangea C, Petrescu AJ, Seidler DG, Munteanu CV, Zamfir ADFlangea C et al . "Identification of an unusually sulfated tetrasaccharide chondroitin/dermatan motif in mouse brain by combining chip-nanoelectrospray multistage MS2 -MS4 and high resolution MS", Electrophoresis 34(11): 1581‐1592, (2013)
    IF: 3.16AI: 0.60
View all papers

Grants

Mass spectrometry based investigation of the oxidative stress as a potential key-player in the immunobiology of melanoma 02/05/2018 - 31/08/2020
Acronym: IMUNOPEP
Budget: 250 000 RON
Project director: Cristian Munteanu

Role of TG2 in cancer tumor microenvironment for guiding metastasis prevention therapeutic approaches 2020-2022
Acronym: TG2TARGET
Budget: 431,900 RON
Project director: Livia Sima

The overall goal of the current project is to understand the impact of tissue transglutaminase (TG2) targeting in the context of ovarian cancer (OC) tumor microenvironment (TME). Our aproach is aimed at testing the hypothesis that interventions in targeting TG2 in the OC TME will disrupt pro-tumorigenic signaling cross-talk within tumors.

Context-dependent therapeutic targeting of ovarian cancer metastasis using TG2 small molecule inhibitors 2020-2022
Acronym: TG2THERAPY
Budget: 600,000 RON
Project director: Livia Sima

The principal goal of this project is the development of a new class of small molecule inhibitors (SMIs) targeting TG2-FN interaction, which is currently in the phase of lead optimization, translatable to clinical use for prevention of ovarian cancer dissemination, either alone or in combinations.

Molecular mechanisms of protein aggregation and unconventional secretion in the context of inflammation and neurodegenerative disorders 2021-2023
Acronym: AggrInflam
Budget: 431.900 RON
Project director: Marioara Chiritoiu-Butnaru

This project aims to understand the molecular events associated with protein aggregation and how a Golgi located protein along with the UPR pathway modulate this process. Model proteins such as IL-1β and α-synuclein, previously shown to aggregate will be employed for these studies. Achieving the objectives of this project should facilitate the understanding of the signaling pathways and the sequence of events correlating the stress sensing machinery with cytoplasmic proteome instability.