Romanian Academy
Stefan Szedlacsek, Dr.
Group: Enzymology
Department: EnzymologyHead of Department
Research interests: TBA, Researcher | Teaching staff | Scientific reviewer | Manager | Consultant.
Currently working on
Institute of Biochemistry of the Romanian Academy , Bucharest.
Department of Enzymology .
Department of Enzymology .
Biography
Professor Dr. Stefan Eugen Szedlacsek is the Head of the Enzymology Department at the Institute of Biochemistry of the Romanian Academy. He holds a PhD degree in Biotechnology from Polytechnic University of Bucharest as well as a MSc in Organic Synthesis (Polytechnic University- Bucharest) and MSc in Mathematics (Bucharest University). As a visiting scientist, he performed research in the field of cholesterol metabolism University of Illinois at Urbana-Champaign (USA), where he succeeded to evidence a new pathway in the metabolism of oxysterols. He is an “Alexander von Humboldt“ fellow and worked in Germany, in the Institute of Biochemistry (Kiel University), Max-Plack Institute for Physiological Chemistry (Dortmund) and Max-Planck Institute for Biophysics (Frankfurt) where he solved the crystal structure of PTP-SL/PTPBR7 catalytic domain, the first structure of a KIM-containing Protein Tyrosine Phosphatases PTP), and demonstrated the lateral dimerization of extracellular region of receptor-like PTP μ. Currently, Professor Szedlacsek and his team studies structure-function relationship in enzymes involved in cellular signaling. He has supervised numerous PhD and master’s theses. Together with his group, he participated as Principal Investigator/Group Leader in the Marie Curie Research Training Networks - PTPNET; MRTN-CT- 2006-035830 (FP6), financed by the European Community. Also, he received a „P-CUBE TNA Project” Fellowship (FP 7- EU) from Oxford University (United Kingdom). Professor Szedlacsek was Project Coordinator for research consortia within a number of projects financed by the Romanian Research Authority.
Papers
- . Regulation of TRPM8 channel activity by Src-mediated tyrosine phosphorylation. Journal of Cellular Physiology, 2020, 235(6): 5192-5203IF=4.52
- . Biological and molecular modifications induced by cadmium and arsenic during breast and prostate cancer development. Environ Res, 2019, 178: 108700IF=5.03
- . Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation. International Journal of Molecular Sciences, 2019, 20(24): 6307IF=4.18
- . Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate. Journal of Structural Biology, 2019, 207(1): 85-102IF=3.75
- . Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR-377/VE-PTP axis. Journal of cellular and molecular medicine, 2018, 22(10): 4700-4708IF=4.66
- . WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton. Scientific reports, 2018, 8(1): 2910
- . Expression, Purification, and Kinetic Analysis of PTP Domains. Methods in molecular biology (Clifton, N.J.), 2016, 1447: 39-66
- . Phosphoketolases from Lactococcus lactis, Leuconostoc mesenteroides and Pseudomonas aeruginosa: Dissimilar sequences, similar substrates but distinct enzymatic characteristics. Applied Microbiology and Biotechnology, 2014, 18(98): 7855-67IF=3.34
- . Analysis of molecular determinants of PRL-3. Journal of cellular and molecular medicine, 2009, 13(9B): 3141-50
Grants
” Reconstruction of Ancestor of Receptor Protein Tyrosine Phosphatase Catalytic Domain ”
2011-2016
Acronym: Contract: 296/2011, Cod Depunere: PN-II-ID-PCE-2011-3-0743
Project director: Stefan Szedlacsek
Synthesis of the ancestral PTP catalytic domain and its characterization both in vitro and in vivo.
„ Compound for inhibition of certain signaling processes related to the evolution of the cognitive processes ”
2017-2018
Acronym: Ctr.327/27.03.2017/Company CRU SRL, Medical Services Company/ Dunakesz, Hungary
Project director: Stefan Szedlacsek
Molecular modeling of a set of peptides that can disrupt the GluA2-Cterm complex with STEP (Complex A) or BRAG2 (ComplexB).
" Novel radiolabeled affibodies for targeted imaging and therapy "
2019-2021
Acronym: Acord bilateral nr.3698/13.09.2018 Academia Romana- Academia Ungara de Stiinte
Project director: Stefan Szedlacsek
The project is agreed as a joint collaboration among IBAR and ATOMKI, UD and IFIN-HH is a cost free participant. There are two main directions envisaged by the proposed project: receptors mapping and therapy, using an affibody against HER2 receptor, combined with an adequate radioisotope. In this respect, the specific objectives are: a) expression and purification of affibodies; b) establish labeling procedures; c) ex vivo and/or in vivo testing of optimal compounds.
" Structure, Regulation, and Biological Function ".
2007-2011
Acronym: PTPNET
Project director: Stefan Szedlacsek
PTPs are proteins with enzymatic properties and a range of cell and tissue functions.