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Stefan Szedlacsek, Dr.

Stefan Szedlacsek
Group: Enzymology
Department: Enzymology

Head of Department

Research interests: TBA, Researcher | Teaching staff | Scientific reviewer | Manager | Consultant.

Currently working on

Institute of Biochemistry of the Romanian Academy , Bucharest.
Department of Enzymology .

Biography

Professor Dr. Stefan Eugen Szedlacsek is the Head of the Enzymology Department at the Institute of Biochemistry of the Romanian Academy. He holds a PhD degree in Biotechnology from Polytechnic University of Bucharest as well as a MSc in Organic Synthesis (Polytechnic University- Bucharest) and MSc in Mathematics (Bucharest University). As a visiting scientist, he performed research in the field of cholesterol metabolism University of Illinois at Urbana-Champaign (USA), where he succeeded to evidence a new pathway in the metabolism of oxysterols. He is an “Alexander von Humboldt“ fellow and worked in Germany, in the Institute of Biochemistry (Kiel University), Max-Plack Institute for Physiological Chemistry (Dortmund) and Max-Planck Institute for Biophysics (Frankfurt) where he solved the crystal structure of PTP-SL/PTPBR7 catalytic domain, the first structure of a KIM-containing Protein Tyrosine Phosphatases PTP), and demonstrated the lateral dimerization of extracellular region of receptor-like PTP μ. Currently, Professor Szedlacsek and his team studies structure-function relationship in enzymes involved in cellular signaling. He has supervised numerous PhD and master’s theses. Together with his group, he participated as Principal Investigator/Group Leader in the Marie Curie Research Training Networks - PTPNET; MRTN-CT- 2006-035830 (FP6), financed by the European Community. Also, he received a „P-CUBE TNA Project” Fellowship (FP 7- EU) from Oxford University (United Kingdom). Professor Szedlacsek was Project Coordinator for research consortia within a number of projects financed by the Romanian Research Authority.

Papers

Year
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Grants

” Reconstruction of Ancestor of Receptor Protein Tyrosine Phosphatase Catalytic Domain ” 2011-2016
Acronym: Contract: 296/2011, Cod Depunere: PN-II-ID-PCE-2011-3-0743
Project director: Stefan Szedlacsek

Synthesis of the ancestral PTP catalytic domain and its characterization both in vitro and in vivo.

„ Compound for inhibition of certain signaling processes related to the evolution of the cognitive processes ” 2017-2018
Acronym: Ctr.327/27.03.2017/Company CRU SRL, Medical Services Company/ Dunakesz, Hungary
Project director: Stefan Szedlacsek

Molecular modeling of a set of peptides that can disrupt the GluA2-Cterm complex with STEP (Complex A) or BRAG2 (ComplexB).

" Novel radiolabeled affibodies for targeted imaging and therapy " 2019-2021
Acronym: Acord bilateral nr.3698/13.09.2018 Academia Romana- Academia Ungara de Stiinte
Project director: Stefan Szedlacsek

The project is agreed as a joint collaboration among IBAR and ATOMKI, UD and IFIN-HH is a cost free participant. There are two main directions envisaged by the proposed project: receptors mapping and therapy, using an affibody against HER2 receptor, combined with an adequate radioisotope. In this respect, the specific objectives are: a) expression and purification of affibodies; b) establish labeling procedures; c) ex vivo and/or in vivo testing of optimal compounds.

" Structure, Regulation, and Biological Function ". 2007-2011
Acronym: PTPNET
Project director: Stefan Szedlacsek

PTPs are proteins with enzymatic properties and a range of cell and tissue functions.