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Ioan Valentin Matei, M.D., Ph.D.

Ioan Valentin Matei
Group: Systems Biology of Aging
Department: Bioinformatics & Structural Biochemistry

Assistant Researcher

Research interests: Biogerontology/ageing research, synthetic biology, C.elegans modeling, regenerative medicine and stem cell science, cell therapies for diabetes


Ioan has a background in regenerative medicine, cell therapies, stem cell science and diabetes research. He has worked extensively on endocrine pancreatic cell differentiation, starting with his Ph.D. at the Nippon Dental University Graduate School at Tokyo, where he studied dental-derived mesenchymal stem cell differentiation into endocrine pancreatic cells, and devising an in vitro model of glucotoxicity mitigation, as a recipient of the Japanese Government MEXT Scholarship. During his postdoctoral years, he worked at the Center for Gene and Cellular Therapies in the Treatment of Cancer OncoGen Timisoara, part of the CAR-NK project’s stem cell group coordinated by Prof. Virgil Paunescu, and then at Titu Maiorescu University’s Acad. N. Cajal Institute of Medical Research Bucharest and Fundeni Clinical Institue’s Center of Excellence in Translational Medicine, studying the modulation of liver-to-pancreas transdifferentiation for diabetics, as part of the Dia-Cure project coordinated by Prof. Sarah Ferber of Sheba Medical Center at Tel Hashomer and The Sackler School of Medicine at Tel Aviv University.
Ioan developed an interest in ageing research and synthetic biology, and is currently a member of the Systems Biology of Aging Group led by Dr. Robi Tacutu, working with CPIII Dr. Simona Ghenea on CRISPR-based gene editing for corroborating models of synergistic gene interaction generated through bioinformatic modeling for regulating longevity in Caenorhabditis elegans.


  • Hydrogen sulfide enhances pancreatic β-cell differentiation from human tooth under normal and glucotoxic conditions., Regenerative medicine, 12(2), 125-141, 2017
    Matei IV, Ii H, Yaegaki K
  • Contributions of evolutionary biology to the understanding of cancer., Proceedings of the Romanian Academy Series B, 3(14), 183-190, 2012
    Ionescu-Tirgoviste C, Matei IV, Ivanus B, Falcan AM.
  • Correlations of visfatin with the lipidic metabolism in diabetic and obese patients., Proceedings of the Romanian Academy Series B, 1(14), 37-43, 2012
    Gligor R, Zdremtan D, Pilat L, Matei I, Ionescu-Tirgoviste C, Crisnic I.
  • A cytomorphometric analysis of adipocytes from the omental and abdominal subcutaneous adipose tissue, Proceedings of the Romanian Academy Series B, 3(13), 212-236, 2011
    Ionescu-Tirgoviste C, Matei IV, Gubceac E, Militaru M, Gutu D, Lixandru D.


Gerontomics: Multi-omics prediction system for prioritization of gerontological interventions 2016-2021
Acronym: Gerontomics
Project director: Robi Tacutu

Starting 02.09.2016, the Institute of Biochemistry of the Romanian Academy is implementing the project “Multi-omics prediction system for prioritization of gerontological interventions”, co-funded through European Fund for Regional Development, in accordance with the funding contract signed by the Ministry of National Education and Scientific Research. The total funding for the project is 8.524.757,50 lei, of which 8.502.557,50 lei represent non-reimbursable funding. The project’s duration is 48 months.