Ioan Valentin Matei, M.D., Ph.D.
Group: Systems Biology of AgingDepartment: Bioinformatics & Structural Biochemistry
During his postdoctoral years, he worked at OncoGen Timisoara, and then as part of the Dia-Cure project at Titu Maiorescu University’s Cajal Institute and CEMT Fundeni, headed by Prof. Sarah Ferber of Sheba Medical Center, Tel Aviv University and Orgenesis Ltd, studying the modulation of diabetic liver-to-pancreas transdifferentiation.
Ioan currently works in aging research and synthetic biology as part of the Systems Biology of Aging Group, assessing longevity-promoting genetic interventions in C. elegans for corroborating synergistic gene interactions generated through bioinformatic modelling, as well as automating C.elegans lifespan measurements for interventional studies of age-related diseases.
. "The role of DNA demethylation in liver to pancreas transdifferentiation", Stem cell research & therapy 13(1): 476, (2022)
. "Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans", Aging 13(undefined), (2021)
. "Phenotypic assessment of liver-derived cell cultures during in vitro expansion", Regenerative medicine, (2021)
. "The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation", Regenerative medicine, (2021)
. "Hydrogen sulfide enhances pancreatic β-cell differentiation from human tooth under normal and glucotoxic conditions", Regenerative medicine 12(2): 125-141, (2017)
. "Contributions of evolutionary biology to the understanding of cancer", Proceedings of the Romanian Academy Series B 3(14): 183-190, (2012)
. "Correlations of visfatin with the lipidic metabolism in diabetic and obese patients", Proceedings of the Romanian Academy Series B 1(14): 37-43, (2012)
. "A cytomorphometric analysis of adipocytes from the omental and abdominal subcutaneous adipose tissue", Proceedings of the Romanian Academy Series B 3(13): 212-236, (2011)
Starting 02.09.2016, the Institute of Biochemistry of the Romanian Academy is implementing the project “Multi-omics prediction system for prioritization of gerontological interventions”, co-funded through European Fund for Regional Development, in accordance with the funding contract signed by the Ministry of National Education and Scientific Research. The total funding for the project is 8.524.757,50 lei, of which 8.502.557,50 lei represent non-reimbursable funding. The project’s duration is 48 months.
The project aims to experimentally develop an integrated and automated solution for screening drugs and genetic interventions for neurodegenerative diseases, using the nematode C. elegans and ageing-related data.