Catalin Lazar, PhD
Oral administration of a chimeric Hepatitis B Virus S/preS1 antigen produced in lettuce triggers infection neutralizing antibodies in mice., Vaccine, 36(38), 5789-5795, 2018Dobrica MO, Lazar C, Paruch L, van Eerde A, Clarke JL, Tucureanu C, Caras I, Ciulean S, Onu A, Tofan V, Branzan A, Urban S, Stavaru C, Branza-Nichita N
Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination., Plant biotechnology journal, 15(12), 1611-1621, 2017Clarke JL, Paruch L, Dobrica MO, Caras I, Tucureanu C, Onu A, Ciulean S, Stavaru C, Eerde A, Wang Y, Steen H, Haugslien S, Petrareanu C, Lazar C, Popescu CI, Bock R, Dubuisson J, Branza-Nichita N
Novel function of the endoplasmic reticulum degradation-enhancing α-mannosidase-like proteins in the human hepatitis B virus life cycle, mediated by the middle envelope protein., Cellular microbiology, 19(2), 2017Lazar C, Uta M, Petrescu SM, Branza-Nichita N
Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide., Journal of medical virology, 85(5), 780-8, 2013Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita N
Activation of ERAD pathway by human hepatitis B virus modulates viral and subviral particle production., PloS one, 7(3), e34169, 2012Lazar C, Macovei A, Petrescu S, Branza-Nichita N
Antiviral activity of lactoferrin against bovine viral diarrhea virus, Romanian Jornal of Biochemistry(42), 21-29, 2005Raducanu A, Stoica C, Icriverzi M, Lazar C, Nichita N, Roseanu A.
We aim to produce high yields of novel HBV/HCV antigens with superior immunogenic properties in plants and mammalian cells, based on innovative molecular design and establish in premiere an advanced biotechnological platform for production of best vaccine candidates antigens in algae.