Romanian Academy
Rodica-Aura Badea, Dr.
Biography
Papers
- . WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton. Scientific reports, 2018, 8(1):2910.
- . Expression, Purification, and Kinetic Analysis of PTP Domains. Methods in molecular biology (Clifton, N.J.), 2016, 1447:39-66.
Grants
Synthesis of the ancestral PTP catalytic domain and its characterization both in vitro and in vivo.
Molecular modeling of a set of peptides that can disrupt the GluA2-Cterm complex with STEP (Complex A) or BRAG2 (ComplexB).
The project is agreed as a joint collaboration among IBAR and ATOMKI, UD and IFIN-HH is a cost free participant. There are two main directions envisaged by the proposed project: receptors mapping and therapy, using an affibody against HER2 receptor, combined with an adequate radioisotope. In this respect, the specific objectives are: a) expression and purification of affibodies; b) establish labeling procedures; c) ex vivo and/or in vivo testing of optimal compounds.
PTPs are proteins with enzymatic properties and a range of cell and tissue functions.