Romanian Academy
Mari Chiritoiu, Dr.
Group: Molecular Cell Biology
Department: Molecular Cell BiologySenior Reseacher III
Research interests: Membrane trafficking, Inflammation, Neurodegeneration
Biography
Dr. Chiritoiu graduated from Faculty of Chemistry, University of Bucharest (2004-2008) and received her Ph.D. in Biology from the Institute of Biochemistry of the Romanian Academy in 2014, under the supervision of dr. Stefana Petrescu. She was a posdoctoral fellow in the lab of prof. Vivek Malhotra, at CRG-Centre for Genomic Regulation, Barcelona, Spain (2016-2019) where she investigated the process of unconventional protein secretion using as model cargo the pro-inflammatory cytokine interleukin-1β.
In the future, dr. Chiritoiu aims to understand key aspects of the molecular mechanism of leaderless protein export, such as interleukin-1β and α-synuclein, related to inflammation and neurodegeneration.
In the future, dr. Chiritoiu aims to understand key aspects of the molecular mechanism of leaderless protein export, such as interleukin-1β and α-synuclein, related to inflammation and neurodegeneration.
Papers
- . GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion. Developmental cell, 2019, 49(1): 145-155.e4IF=9.19
- . Unconventional secretion of FABP4 by endosomes and secretory lysosomes. The Journal of cell biology, 2018, 217(2): 649-665IF=8.89
- . Inhibition of N-glycan processing modulates the network of EDEM3 interactors. Biochemical and biophysical research communications, 2017, 486(4): 978-984IF=2.56
- . Chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2017, 68(3): 385-395IF=2.48
- . Antimicrobial polycaprolactone/polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering. Applied Surface Science, 2017, 417: 234-243
- . Biocomposite coatings based on Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering. Applied Surface Science, 2017, 417: 204-212
- . Long-term exposure to CXCL2 has cytotoxic effects on HEK293T cells stably expressing TRPV1. Romanian Biotechnological letters, 2017
- . Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) - lysozyme microspheres based coatings with anti-microbial properties. International journal of pharmaceutics, 2017, 521(1-2): 184-195
- . Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region. PloS one, 2012, 7(8): e42998
- . C-terminus glycans with critical functional role in the maturation of secretory glycoproteins. PloS one, 2011, 6(5): e19979IF=4.09