Romanian Academy
Mari Chiritoiu, Dr.
Group: Molecular Cell Biology
Department: Molecular Cell BiologySenior Reseacher III
Research interests: Membrane trafficking, Inflammation, Neurodegeneration
Biography
Dr. Chiritoiu graduated from Faculty of Chemistry, University of Bucharest (2004-2008) and received her Ph.D. in Biology from the Institute of Biochemistry of the Romanian Academy in 2014, under the supervision of dr. Stefana Petrescu. She was a posdoctoral fellow in the lab of prof. Vivek Malhotra, at CRG-Centre for Genomic Regulation, Barcelona, Spain (2016-2019) where she investigated the process of unconventional protein secretion using as model cargo the pro-inflammatory cytokine interleukin-1β.
In the future, dr. Chiritoiu aims to understand key aspects of the molecular mechanism of leaderless protein export, such as interleukin-1β and α-synuclein, related to inflammation and neurodegeneration.
In the future, dr. Chiritoiu aims to understand key aspects of the molecular mechanism of leaderless protein export, such as interleukin-1β and α-synuclein, related to inflammation and neurodegeneration.
Papers
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GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion., Developmental cell, 49(1), 145-155.e4, 2019Chiritoiu M, Brouwers N, Turacchio G, Pirozzi M, Malhotra VIF=9.19
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Unconventional secretion of FABP4 by endosomes and secretory lysosomes., The Journal of cell biology, 217(2), 649-665, 2018Villeneuve J, Bassaganyas L, Lepreux S, Chiritoiu M, Costet P, Ripoche J, Malhotra V, Schekman RIF=8.891
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Inhibition of N-glycan processing modulates the network of EDEM3 interactors., Biochemical and biophysical research communications, 486(4), 978-984, 2017Butnaru CM, Chiritoiu MB, Chiritoiu GN, Petrescu SM, Petrescu AJIF=2.559
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Chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application., Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 68(3), 385-395, 2017Deftu AF, Filippi A, Shibsaki K, Gheorghe RO, Chiritoiu M, Ristoiu VIF=2.478
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Antimicrobial polycaprolactone/polyethylene glycol embedded lysozyme coatings of Ti implants for osteoblast functional properties in tissue engineering, Applied Surface Science, 417, 234-243, 2017A Visan, R Cristescu, N Stefan, M Miroiu, C Nita, M Socol, C Florica, O Rasoga, I Zgura, LE Sima, M Chiritoiu, MC Chifiriuc, AM Holban, IN Mihailescu, G Socol
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Biocomposite coatings based on Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering, Applied Surface Science, 417, 204-212, 2017O.RașogaaL.SimabM.ChirițoiubG.Popescu-PelincO.FufăcdV.GrumezescucdM.SocolaA.StănculescuaI.ZgurăaG.Socolc
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Long-term exposure to CXCL2 has cytotoxic effects on HEK293T cells stably expressing TRPV1, Romanian Biotechnological letters, 2017ROXANA-OLIMPIA GHEORGHE 1, ALEXANDRA SOCA 1, MARIOARA CHIRIȚOIU 2, ALEXANDRU-FLORIAN DEFTU 1, MARIA-LUIZA FLONTA 1, VIOLETA RISTOIU1 *
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Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) - lysozyme microspheres based coatings with anti-microbial properties., International journal of pharmaceutics, 521(1-2), 184-195, 2017Grumezescu V, Holban AM, Sima LE, Chiritoiu MB, Chiritoiu GN, Grumezescu AM, Ivan L, Safciuc F, Antohe F, Florica C, Luculescu CR, Chifiriuc MC, Socol G
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Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region., PloS one, 7(8), e42998, 2012Marin MB, Ghenea S, Spiridon LN, Chiritoiu GN, Petrescu AJ, Petrescu SM
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C-terminus glycans with critical functional role in the maturation of secretory glycoproteins., PloS one, 6(5), e19979, 2011Cioaca D, Ghenea S, Spiridon LN, Marin M, Petrescu AJ, Petrescu SMIF=4.092