Andrei-José Petrescu, PhD

Andrei-José Petrescu
Group: Bioinformatics & Structural Biochemistry
Department: Bioinformatics & Structural Biochemistry

Head of Department


Andrei heads the Department of Bioinformatics since 1999. He developed computational assisted work relevant in many fields of molecular life sciences reflected by a large web of collaborations with groups from Oxford, Yale, Berkeley, Wageningen and many other advanced research centers.


  • Martin EC, Le Targa L, Tsakou-Ngouafo L, Fan TP, Lin CY, Xiao J, Huang Z, Yuan S, Xu A, Su YH, Petrescu AJ, Pontarotti P, Schatz DGMartin EC et al . "Insights into RAG Evolution from the Identification of "Missing Link" Family A RAGL Transposons", Molecular biology and evolution 40(11): msad232, (2023)
    doi: 10.1093/molbev/msad232
    IF: 10.70AI: 5.06
  • Chiritoiu G., Munteanu CVA., Sulea TA., Spiridon L., Petrescu AJ., Jandus C., Romero P., Petrescu SM.Chiritoiu G. et al . "Methionine oxidation selectively enhances T cell reactivity against a melanoma antigen", iScience(107205), (2023)
    doi: 10.1016/j.isci.2023.107205
    IF: 6.10AI: 1.63
  • Martin EC, Ion CF, Ifrimescu F, Spiridon L, Bakker J, Goverse A, Petrescu AJ.Martin EC et al . "NLRscape: an atlas of plant NLR proteins", Nucleic Acids Res., (2022)
    IF: 19.16AI: 5.51
  • Martin EC, Spiridon L, Goverse A, Petrescu AJ.Martin EC et al . "NLRexpress-A bundle of machine learning motif predictors-Reveals motif stability underlying plant Nod-like receptors diversity", Front Plant Sci. 13: 975888, (2022)
    IF: 6.63AI: 1.17
  • van Grinsven IL, Martin EC, Petrescu AJ, Kormelink R.van Grinsven IL et al . "Tsw - A case study on structure-function puzzles in plant NLRs with unusually large LRR domains", Front Plant Sci 13: 983693, (2022)
    IF: 6.63AI: 1.17
  • Munteanu CVA, Chirițoiu GN, Petrescu AJ, Petrescu ȘMMunteanu CVA et al . "Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition", Frontiers in molecular biosciences 9: 1064868, (2022)
    IF: 6.11AI: 1.33
  • Baudin M, Martin EC, Sass C, Hassan JA, Bendix C, Sauceda R, Diplock N, Specht CD, Petrescu AJ, Lewis JDBaudin M et al . "A natural diversity screen in Arabidopsis thaliana reveals determinants for HopZ1a recognition in the ZAR1-ZED1 immune complex", Plant, cell & environment 44(2): 629-644, (2021)
    IF: 6.16AI: 1.91
  • Munteanu CVA, Chirițoiu GN, Chirițoiu M, Ghenea S, Petrescu AJ, Petrescu ȘMMunteanu CVA et al . "Affinity proteomics and deglycoproteomics uncover novel EDEM2 endogenous substrates and an integrative ERAD network", Molecular & cellular proteomics : MCP: 100125, (2021)
    IF: 5.91AI: 2.26
  • Manica G, Ghenea S, Munteanu CVA, Martin EC, Butnaru C, Surleac M, Chiritoiu GN, Alexandru PR, Petrescu AJ, Petrescu SMManica G et al . "EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning", Int. J. Mol. Sci. 4(22): 2172, (2021)
    IF: 4.56AI: 0.80
  • Manoliu LCE, Martin EC, Milac AL, Spiridon LManoliu LCE et al . "Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor", Molecules (Basel, Switzerland) 26(16), (2021)
    IF: 4.41AI: 0.60
  • Mernea M, Martin EC, Petrescu AJ, Avram SMernea M et al . "Deep Learning in the Quest for Compound Nomination for Fighting COVID-19", Current medicinal chemistry 28(28): 5699-5732, (2021)
    IF: 4.18AI: 0.75
  • Baudin M, Schreiber KJ, Martin EC, Petrescu AJ, Lewis JDBaudin M et al . "Structure-function analysis of ZAR1 immune receptor reveals key molecular interactions for activity", The Plant journal: for cell and molecular biology 101(2): 352-370, (2020)
    IF: 5.70
  • Spiridon L, Şulea TA, Minh DDL, Petrescu AJ.Spiridon L et al . "Robosample: A Rigid-Body Molecular Simulation Program Based on Robot Mechanics", Biochimica Biophysica Acta General Subjects 1864(8): 129616, (2020)
    IF: 3.68AI: 1.40
  • Martin EC, Vicari C, Tsakou-Ngouafo L, Pontarotti P, Petrescu AJ, Schatz DG.Martin EC et al . "Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin", Mobile DNA 11: 17, (2020)
    IF: 3.63AI: 0.90
  • Martin EC, Sukarta OCA, Spiridon L, Grigore LG, Constantinescu V, Tacutu R, Goverse A, Petrescu AJMartin EC et al . "LRRpredictor-A New LRR Motif Detection Method for Irregular Motifs of Plant NLR Proteins Using an Ensemble of Classifiers", Genes (Basel) 11(3): 286, (2020)
    IF: 3.33
  • Zhang Y, Cheng TC, Huang G, Lu Q, Surleac MD, Mandell JD, Pontarotti P, Petrescu AJ, Xu A, Xiong Y, Schatz DGZhang Y et al . "Transposon molecular domestication and the evolution of the RAG recombinase", Nature 569(7754): 79-84, (2019)
    IF: 43.07
  • Ciubotaru M, Musat MG, Surleac M, Ionita E, Petrescu AJ, Abele E, Abele RCiubotaru M et al . "The Design of New HIV-IN Tethered Bifunctional Inhibitors using Multiple Microdomain Targeted Docking", Current medicinal chemistry 26(15): 2574-2600, (2019)
    IF: 3.89
  • Sarbu M, Ica R, Petrut A, Vukelić Ž, Munteanu CVA, Petrescu AJ, Zamfir ADSarbu M et al . "Gangliosidome of human anencephaly: A high resolution multistage mass spectrometry study", Biochimie 163: 142-151, (2019)
    IF: 3.36
  • Munteanu CVA, Chiritoiu GN, Petrescu AJ, Petrescu ȘMMunteanu CVA et al . "Profiling Optimal Conditions for Capturing EDEM Proteins Complexes in Melanoma Using Mass Spectrometry", Advances in experimental medicine and biology 1140: 155-167, (2019)
    IF: 2.13
  • Sarbu M, Dehelean L, Munteanu CVA, Ica R, Petrescu AJ, Zamfir ADSarbu M et al . "Human caudate nucleus exhibits a highly complex ganglioside pattern as revealed by high-resolution multistage Orbitrap MS", Journal of Carbohydrate Chemistry 38(9), (2019)
    IF: 0.80
  • Wróblewski T, Spiridon L, Martin EC, Petrescu AJ, Cavanaugh K, Truco MJ, Xu H, Gozdowski D, Pawłowski K, Michelmore RW, Takken FLWWróblewski T et al . "Genome-wide functional analyses of plant coiled-coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity", PLoS biology 16(12): e2005821, (2018)
    IF: 8.39
  • Slootweg EJ, Spiridon LN, Martin EC, Tameling WIL, Townsend PD, Pomp R, Roosien J, Drawska O, Sukarta OCA, Schots A, Borst JW, Joosten MHAJ, Bakker J, Smant G, Cann MJ, Petrescu AJ, Goverse ASlootweg EJ et al . "Distinct Roles of Non-Overlapping Surface Regions of the Coiled-Coil Domain in the Potato Immune Receptor Rx1", Plant physiology 178(3): 1310-1331, (2018)
    IF: 6.30
  • Eric Norris, Wendell D. Jones, Marius D. Surleac, Andrei José Petrescu, Darla D Destephanis, Qing Zhang, Issam S. Hamadeh, Jeffrey S. Kneisl, Chad Livasy, Ram N. Ganapathi, David L. Tait, Mahrukh K. GanapathiEric Norris et al . "Clonal lineage of high grade serous ovarian cancer in a patient with neurofibromatosis type 1", Gynecologic Oncology Reports 23: 41-44, (2018)
  • Kozuki T, Chikamori K, Surleac MD, Micluta MA, Petrescu AJ, Norris EJ, Elson P, Hoeltge GA, Grabowski DR, Porter ACG, Ganapathi RN, Ganapathi MKKozuki T et al . "Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint", Nucleic acids research 45(10): 5995-6010, (2017)
    IF: 11.56
  • Ruta LL, Kissen R, Nicolau I, Neagoe AD, Petrescu AJ, Bones AM, Farcasanu ICRuta LL et al . "Heavy metal accumulation by Saccharomyces cerevisiae cells armed with metal binding hexapeptides targeted to the inner face of the plasma membrane", Applied microbiology and biotechnology 101(14): 5749-5763, (2017)
    IF: 3.67
  • Butnaru CM, Chiritoiu MB, Chiritoiu GN, Petrescu SM, Petrescu AJButnaru CM et al . "Inhibition of N-glycan processing modulates the network of EDEM3 interactors", Biochemical and biophysical research communications 486(4): 978-984, (2017)
    IF: 2.56
  • De Oliveira AS, Koolhaas I, Boiteux LS, Caldararu OF, Petrescu AJ, Oliveira Resende R, Kormelink RDe Oliveira AS et al . "Cell death triggering and effector recognition by Sw-5 SD-CNL proteins from resistant and susceptible tomato isolines to Tomato spotted wilt virus", Molecular plant pathology 17(9): 1442-1454, (2016)
    IF: 4.70
  • Jeyaraman Rajaraman, Dimitar Douchkov, Götz Hensel, Francesca L. Stefanato, Anna Gordon, Nelzo Ereful, Octav F. Caldararu, Andrei-Jose Petrescu, Jochen Kumlehn, Lesley A. Boyd, Patrick SchweizerJeyaraman Rajaraman et al . "An LRR/Malectin Receptor-Like Kinase Mediates Resistance to Non-adapted and Adapted Powdery Mildew Fungi in Barley and Wheat", Front Plant Sci 7, (2016)
    IF: 4.30
  • Diaz-Granados A, Petrescu AJ, Goverse A, Smant GDiaz-Granados A et al . "SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity", Frontiers in plant science 7: 1575, (2016)
    IF: 4.30
  • Ciubotaru M, Surleac MD, Metskas LA, Koo P, Rhoades E, Petrescu AJ, Schatz DG.Ciubotaru M et al . "The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes", Nucleic Acids Research 43(2): 917-931, (2015)
    IF: 9.20AI: 3.60
  • Sueldo DJ, Shimels M, Spiridon LN, Caldararu O, Petrescu AJ, Joosten MH, Tameling WI. et alSueldo DJ et al . "Random Mutagenesis of the Nucleotide-Binding Domain of NRC1 (NB-LRR Required for Hypersensitive Response-Associated Cell Death-1), a Downstream Signalling Nucleotide-Binding, Leucine-Rich Repeat (NB-LRR) Protein, Identifies Gain-Of-Function Mutations in the Nucleotide-Binding Pocket", New Phytologist 208(1): 210-223, (2015)
    IF: 7.43AI: 2.50
  • Zhang YH, Shetty K, Surleac MD, Petrescu AJ, Schatz DG.Zhang YH et al . "Mapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2", Journal of Biological Chemistry 290(19): 11802‐11817, (2015)
    IF: 4.26AI: 1.60
  • Sarbu M, Munteanu CV, Dehelean L, Petrescu AJ, Peter-Katalinic J, Zamfir AD.Sarbu M et al . "Identification and structural characterization of novel O- and N-glycoforms in the urine of a Schindler disease patient by Orbitrap mass spectrometry", Journal of Mass Spectrometry 50(9): 1044‐1056, (2015)
    IF: 2.54AI: 0.70
  • Sela H, Spiridon LN, Ashkenazi H, Bhullar NK, Brunner S, Petrescu AJ, Fahima T, Keller B, Jordan T.Sela H et al . "Three-dimensional Modeling and Diversity Analysis Reveals Distinct AVR Recognition Sites and Evolutionary Pathways in Wild and Domesticated Wheat Pm3 R Genes", Molecular Plant Microbe Interactions 27(8): 835-845, (2014)
    IF: 3.94AI: 1.30
  • Ciubotaru M, Trexler AJ, Spiridon LN, Surleac MD, Rhoades E, Petrescu AJ, Schatz DG.Ciubotaru M et al . "RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes", Nucleic Acids Research 41(4): 2437-2454, (2013)
    IF: 8.81AI: 3.40
  • Slootweg EJ, Spiridon LN, Roosien J, Butterbach P, Pomp R, Westerhof L, Wilbers R, Bakker E, Bakker J, Petrescu AJ, Smant G, Goverse A.Slootweg EJ et al . "Structural determinants at the interface of the ARC2 and leucine-rich repeat domains control the activation of the plant immune receptors Rx1 and Gpa2", Plant Physiology 162(3): 1510‐1528, (2013)
    IF: 7.39AI: 2.40
  • Flangea C, Petrescu AJ, Seidler DG, Munteanu CV, Zamfir ADFlangea C et al . "Identification of an unusually sulfated tetrasaccharide chondroitin/dermatan motif in mouse brain by combining chip-nanoelectrospray multistage MS2 -MS4 and high resolution MS", Electrophoresis 34(11): 1581‐1592, (2013)
    IF: 3.16AI: 0.60
  • Sela H, Spiridon LN, Petrescu AJ, Akerman M, Mandel-Gutfreund Y, Nevo E, Loutre C, Keller B, Schulman AH, Fahima T.Sela H et al . "Ancient Diversity of Splicing Motifs and Protein Surfaces in the Wild Emmer Wheat (Triticum Dicoccoides) LR10 Coiled Coil (CC) and Leucine-Rich Repeat (LRR) Domains", Molecular Plant Pathology 13(3): 276‐287, (2012)
    IF: 4.49AI: 1.30
  • Marin MB, Ghenea S, Spiridon LN, Chiritoiu GN, Petrescu AJ, Petrescu SMMarin MB et al . "Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region", PloS one 7(8): e42998, (2012)
  • Maekawa T, Cheng W, Spiridon LN, Töller A, Lukasik E, Saijo Y, Liu P, Shen QH, Micluta MA, Somssich IE, Takken FLW, Petrescu AJ, Chai J, Schulze-Lefert PMaekawa T et al . "Coiled-coil domain-dependent homodimerization of intracellular barley immune receptors defines a minimal functional module for triggering cell death", Cell Host Microbe 9(3): 187‐199, (2011)
    IF: 13.50AI: 7.00
  • Grozav AG, Willard BB, Kozuki T, Chikamori K, Micluta MA, Petrescu AJ, Kinter M, Ganapathi R, Ganapathi MK.Grozav AG et al . "Tyrosine 656 in Topoisomerase IIβ Is Important for the Catalytic Activity of the Enzyme: Identification Based on Artifactual +80-Da Modification at This Site", Proteomics 11(5): 829‐842, (2011)
    IF: 4.50AI: 1.00
  • Cioaca D, Ghenea S, Spiridon LN, Marin M, Petrescu AJ, Petrescu SMCioaca D et al . "C-terminus glycans with critical functional role in the maturation of secretory glycoproteins", PloS one 6(5): e19979, (2011)
    IF: 4.09AI: 1.80
  • Slootweg E, Roosien J, Spiridon LN, Petrescu AJ, Tameling W, Joosten M, Pomp R, van Schaik C, Dees R, Borst JW, Smant G, Schots A, Bakker J, Goverse A.Slootweg E et al . "Nucleocytoplasmic Distribution Is Required for Activation of Resistance by the Potato NB-LRR Receptor Rx1 and Is Balanced by Its Functional Domains", Plant Cell 22(12): 4195‐4215, (2010)
    IF: 9.40AI: 4.00
  • Kudla U, Milac AL, Qin L, Overmars H, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant GKudla U et al . "Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis", Molecular plant pathology 8(3): 293-305, (2007)
  • Milac AL, Avram S, Petrescu AJMilac AL et al . "Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors. Application to HIV-1 protease inhibitors", Journal of molecular graphics & modelling 25(1): 37-45, (2006)
    AI: 0.90
  • Jaubert S, Milac AL, Petrescu AJ, de Almeida-Engler J, Abad P, Rosso MNJaubert S et al . "In planta secretion of a calreticulin by migratory and sedentary stages of root-knot nematode", Molecular plant-microbe interactions : MPMI 18(12): 1277-84, (2005)
  • Costin GE, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Vieira WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJCostin GE et al . "Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein", The Biochemical journal 391(Pt 2): 249-59, (2005)
  • Kudla U, Qin L, Milac A, Kielak A, Maissen C, Overmars H, Popeijus H, Roze E, Petrescu A, Smant G, Bakker J, Helder JKudla U et al . "Origin, distribution and 3D-modeling of Gr-EXPB1, an expansin from the potato cyst nematode Globodera rostochiensis", FEBS letters 579(11): 2451-7, (2005)
  • Petrescu A-J, Milac AL, Petrescu SM, Dwek RA, Wormald MRPetrescu A-J et al . "Statistical analysis of the protein core around N-glycosylation sites. Implications on occupancy, folding and function", Glycobiology 14: 103-114, (2004)
  • Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MRPetrescu AJ et al . "Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding", Glycobiology 14(2): 103-14, (2004)
  • Petrescu SM, Popescu CI, Petrescu A-J, Dwek RAPetrescu SM et al . "The glycosylation of tyrosinase in melanoma cells and the effect on antigen presentation", Adv. Exp. Med. Biol 535: 257-269, (2003)
  • Hinsen K, Petrescu A-J, Dellerue S, Belissent-Funel MC, Kneller GRHinsen K et al . "Liquid-like and solid-like motions in proteins", J.Mol. Liquids 98-99: 381-398, (2002)
  • Wormald MR, Petrescu AJ, Pao YL, Glithero A, Elliott T, Dwek RAWormald MR et al . "Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling", Chemical reviews 102(2): 371-86, (2002)
  • Dellerue S, Petrescu AJ, Smith JC, Bellissent-Funel MCDellerue S et al . "Radially softening diffusive motions in a globular protein", Biophysical journal 81(3): 1666-76, (2001)
  • Dellerue S, Petrescu A-J, Smith JC, Longeville S, Bellissent-Funel M-CDellerue S et al . "Collective Dynamics of a Photosyntethic Protein Probed by Neutron Spin-Echo Spectroscopy and Molecular Dynamics Simulation", Physica B. 276-278: 514-515, (2000)
  • Hinsen K, Petrescu A-J, Delerue S, Bellissent-Funel M-C, Kueller GRHinsen K et al . "Harmonicity in slow protein dynamics", Chem.Phys.(261): 25-37, (2000)
  • Branza-Nichita N, Petrescu AJ, Negroiu G, Dwek RA, Petrescu SMBranza-Nichita N et al . "N-glycosylation processing and glycoprotein folding-lessons from the tyrosinase-related proteins", Chemical reviews 100(12): 4697-712, (2000)
  • Petrescu AJ, Calmettes P, Durand D, Receveur V, Smith JCPetrescu AJ et al . "Change in backbone torsion angle distribution on protein folding", Protein science : a publication of the Protein Society 9(6): 1129-36, (2000)
  • Petrescu SM, Branza-Nichita N, Negroiu G, Petrescu AJ, Dwek RAPetrescu SM et al . "Tyrosinase and glycoprotein folding: roles of chaperones that recognize glycans", Biochemistry 39(18): 5229-37, (2000)
  • Branza-Nichita N, Negroiu G, Petrescu AJ, Garman EF, Platt FM, Wormald MR, Dwek RA, Petrescu SMBranza-Nichita N et al . "Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control", The Journal of biological chemistry 275(11): 8169-75, (2000)
  • Dellerues S, Petrescu A-J, Smith JC, Longenille S, Bellisent-Funnel MCDellerues S et al . "Collective dynamics of a photosintetic protein probed by NES spectroscopy and MD simulation", Physica B 276-278: 514-515, (1999)
  • Nichita-Branza N, Petrescu A-J, Dwek RA, Wormald M, Platt F, Petrescu S-MNichita-Branza N et al . "Tyrosinase folding and copper loading in vivo: a crucial role for calnexin and a-glucosidase II", Biochem. Biophys. Res. Commun.(261): 720-725, (1999)
  • Negroiu G, Branza-Nichita N, Costin GE, Titu H, Petrescu AJ, Dwek RA, Petrescu SMNegroiu G et al . "Investigation of the intracellular transport of tyrosinase and tyrosinase related protein (TRP)-1. The effect of endoplasmic reticulum (ER)-glucosidases inhibition", Cellular and molecular biology (Noisy-le-Grand, France) 45(7): 1001-10, (1999)
  • Negroiu G, Branza-Nichita N, Petrescu AJ, Dwek RA, Petrescu SMNegroiu G et al . "Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells", The Biochemical journal 344 Pt 3: 659-65, (1999)
  • Petrescu AJ, Petrescu SM, Dwek RA, Wormald MRPetrescu AJ et al . "A statistical analysis of N- and O-glycan linkage conformations from crystallographic data", Glycobiology 9(4): 343-52, (1999)
  • Petrescu AJ, Butters TD, Reinkensmeier G, Petrescu S, Platt FM, Dwek RA, Wormald MRPetrescu AJ et al . "The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding", The EMBO journal 16(14): 4302-10, (1997)
  • Petrescu SM, Petrescu AJ, Titu HN, Dwek RA, Platt FMPetrescu SM et al . "Inhibition of N-glycan processing in B16 melanoma cells results in inactivation of tyrosinase but does not prevent its transport to the melanosome", The Journal of biological chemistry 272(25): 15796-803, (1997)
  • Albulescu R, Petrescu AJ, Sârbu M, Grigore A, Ica R, Munteanu CVA, Albulescu A, Militaru IV, Zamfir AD, Petrescu SM, Tănase CAlbulescu R et al . "Mass Spectrometry for Cancer Biomarkers", pp 477, Proteomics Technologies and Applications, InTechOpen, (2019).
    ISBN: 978-1-78984-611-9
  • Surleac MD, Spiridon LN, TacutuR, Milac AL, Petrescu SM, Petrescu AJSurleac MD et al . "Structural Assessment of Glycosylation Sites Database - SAGS – An Overall View on N-Glycosylation", pp 3-20, Glycosilation, InTech, (2012).
    ISBN: 978-953-51-0771-2
  • Petrescu SM, Petrescu A-J, Platt FM, Dwek RAPetrescu SM et al . pp 41-42, Glycosylation and Glycoprotein Folding, Wellcome Trust Reviews, (2000).
    ISBN: 184129019X
View all papers


Structure Assisted Investigation of Critical Protein Families Involved in Plant Immunity 2017-2019
Project director: Andrei-José Petrescu

This project aims to address a number of structural aspects related to key elements of the plant immune system and its pathogen interactors using a combined approach intricating experimental and computational steps. To this end we intend to build on our previous results in the field and further develop experimental, bioinformatics and molecular modeling methods appropriate for solving the specific problems implied by this proposal.

Identification of new molecules involved in melanoma associated antigens production 2020-2022
Acronym: ImmunoMOD
Budget: 246,950 RON
Project director: Gabriela Chiritoiu

This project aims to develop new strategies to improve the capacity of antigen presenting tumor cells to activate cytotoxic T cells and hamper immune escape mechanisms in cancer.