Adina-Luminita Milac, Ph.D habil

Biography

Papers

• Famiglietti AL, Wei Z, Beres TM, Milac AL, Tran DT, Patel D, Angerer RC, Angerer LM, Tabak LAFamiglietti AL et al. Characterization and expression analysis of Galnts in developing Strongylocentrotus purpuratus embryos. PloS one, 2017, 12(4): e0176479IF=2.77
• Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu GPopa IL et al. Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression. The Journal of biological chemistry, 2016, 291(24): 12481-500IF=4.12
• Avram S, Borcan F, Borcan LC, Milac AL, Mihailescu DAvram S et al. QSAR Approaches Applied to Antidepressants Induced Neurogenesis--in vivo and in silico Applications. Mini reviews in medicinal chemistry, 2015, 16(3): 230-40
• Avram S, Milac A, Mernea M, Mihailescu D, Putz MV, Buiu CAvram S et al. Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control. International journal of molecular sciences, 2014, 15(11): 21381-400
• Milac AL, Bojarska E, Wypijewska del Nogal AMilac AL et al. Decapping Scavenger (DcpS) enzyme: advances in its structure, activity and roles in the cap-dependent mRNA metabolism. Biochimica et biophysica acta, 2014, 1839(6): 452-62
• Filimon A, Zurac SA, Milac AL, Sima LE, Petrescu SM, Negroiu GFilimon A et al. Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. Melanoma research, 2014, 24(3): 219-36
• Wypijewska del Nogal A, Surleac MD, Kowalska J, Lukaszewicz M, Jemielity J, Bisaillon M, Darzynkiewicz E, Milac AL, Bojarska EWypijewska del Nogal A et al. Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding. The FEBS journal, 2013, 280(24): 6508-27IF=3.99
• Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita NFlorian PE et al. Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide. Journal of medical virology, 2013, 85(5): 780-8IF=2.22
• Avram S, Milac AL, Carta F, Supuran CTAvram S et al. More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design. Journal of enzyme inhibition and medicinal chemistry, 2013, 28(2): 350-9
• Avram S, Milac AL, Mihailescu DAvram S et al. 3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A. Molecular bioSystems, 2012, 8(5): 1418-25IF=3.35
• Avram S, Buiu C, Borcan F, Milac ALAvram S et al. More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis. Molecular bioSystems, 2012, 8(2): 587-94
• Milac A, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HRMilac A et al. Structural models of TREK channels and their gating mechanism. Channels (Austin, Tex.), 2011, 5(1): 23-33
• Maksaev G, Milac A, Anishkin A, Guy HR, Sukharev SMaksaev G et al. Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models. Channels (Austin, Tex.), 2011, 5(1): 34-42
• Anishkin A, Milac AL, Guy HRAnishkin A et al. Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels. Proteins, 2010, 78(4): 932-49
• Kudla U, Milac AL, Qin L, Overmars H, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant GKudla U et al. Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis. Molecular plant pathology, 2007, 8(3): 293-305
• Milac AL, Buchete NV, Fritz TA, Hummer G, Tabak LAMilac AL et al. Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2. Journal of molecular biology, 2007, 373(2): 439-51
• Milac AL, Avram S, Petrescu AJMilac AL et al. Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors. Application to HIV-1 protease inhibitors. Journal of molecular graphics & modelling, 2006, 25(1): 37-45
• Jaubert S, Milac AL, Petrescu AJ, de Almeida-Engler J, Abad P, Rosso MNJaubert S et al. In planta secretion of a calreticulin by migratory and sedentary stages of root-knot nematode. Molecular plant-microbe interactions : MPMI, 2005, 18(12): 1277-84
• Costin GE, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Vieira WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJCostin GE et al. Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein. The Biochemical journal, 2005, 391(Pt 2): 249-59
• Kudla U, Qin L, Milac A, Kielak A, Maissen C, Overmars H, Popeijus H, Roze E, Petrescu A, Smant G, Bakker J, Helder JKudla U et al. Origin, distribution and 3D-modeling of Gr-EXPB1, an expansin from the potato cyst nematode Globodera rostochiensis. FEBS letters, 2005, 579(11): 2451-7
• Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MRPetrescu AJ et al. Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding. Glycobiology, 2004, 14(2): 103-14
• Adina L. Milac, Gabriela Negroiu. Human Skin Cancers: Pathways, Mechanisms, Targets and Treatments in The Multiple Roles of Tyrosinase-Related Protein-2/LDopachrome Tautomerase in Melanoma: Biomarker, Therapeutic Target, and Molecular Driver in Tumor Progression, 2018(3), IntechOpen: 22-33

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