Adina-Luminita Milac, Ph.D habil

Biography

Papers

• Characterization and expression analysis of Galnts in developing Strongylocentrotus purpuratus embryos., PloS one, 12(4), e0176479, 2017
  Famiglietti AL, Wei Z, Beres TM, Milac AL, Tran DT, Patel D, Angerer RC, Angerer LM, Tabak LA
• Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression., The Journal of biological chemistry, 291(24), 12481-500, 2016
  Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu G
• QSAR Approaches Applied to Antidepressants Induced Neurogenesis--in vivo and in silico Applications., Mini reviews in medicinal chemistry, 16(3), 230-40, 2015
  Avram S, Borcan F, Borcan LC, Milac AL, Mihailescu D
• Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control., International journal of molecular sciences, 15(11), 21381-400, 2014
  Avram S, Milac A, Mernea M, Mihailescu D, Putz MV, Buiu C
• Decapping Scavenger (DcpS) enzyme: advances in its structure, activity and roles in the cap-dependent mRNA metabolism., Biochimica et biophysica acta, 1839(6), 452-62, 2014
  Milac AL, Bojarska E, Wypijewska del Nogal A
• Value of dopachrome tautomerase detection in the assessment of melanocytic tumors., Melanoma research, 24(3), 219-36, 2014
  Filimon A, Zurac SA, Milac AL, Sima LE, Petrescu SM, Negroiu G
• Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding., The FEBS journal, 280(24), 6508-27, 2013
  Wypijewska del Nogal A, Surleac MD, Kowalska J, Lukaszewicz M, Jemielity J, Bisaillon M, Darzynkiewicz E, Milac AL, Bojarska E
• Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide., Journal of medical virology, 85(5), 780-8, 2013
  Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita N
• More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design., Journal of enzyme inhibition and medicinal chemistry, 28(2), 350-9, 2013
  Avram S, Milac AL, Carta F, Supuran CT
• 3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A., Molecular bioSystems, 8(5), 1418-25, 2012
  Avram S, Milac AL, Mihailescu D
• More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis., Molecular bioSystems, 8(2), 587-94, 2012
  Avram S, Buiu C, Borcan F, Milac AL
• Structural models of TREK channels and their gating mechanism., Channels (Austin, Tex.), 5(1), 23-33, 2011
  Milac A, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HR
• Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models., Channels (Austin, Tex.), 5(1), 34-42, 2011
  Maksaev G, Milac A, Anishkin A, Guy HR, Sukharev S
• Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels., Proteins, 78(4), 932-49, 2010
  Anishkin A, Milac AL, Guy HR
• Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis., Molecular plant pathology, 8(3), 293-305, 2007
  Kudla U, Milac AL, Qin L, Overmars H, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant G
• Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2., Journal of molecular biology, 373(2), 439-51, 2007
  Milac AL, Buchete NV, Fritz TA, Hummer G, Tabak LA
• Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors. Application to HIV-1 protease inhibitors., Journal of molecular graphics & modelling, 25(1), 37-45, 2006
  Milac AL, Avram S, Petrescu AJ
• In planta secretion of a calreticulin by migratory and sedentary stages of root-knot nematode., Molecular plant-microbe interactions : MPMI, 18(12), 1277-84, 2005
  Jaubert S, Milac AL, Petrescu AJ, de Almeida-Engler J, Abad P, Rosso MN
• Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein., The Biochemical journal, 391(Pt 2), 249-59, 2005
  Costin GE, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Vieira WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJ
• Origin, distribution and 3D-modeling of Gr-EXPB1, an expansin from the potato cyst nematode Globodera rostochiensis., FEBS letters, 579(11), 2451-7, 2005
  Kudla U, Qin L, Milac A, Kielak A, Maissen C, Overmars H, Popeijus H, Roze E, Petrescu A, Smant G, Bakker J, Helder J
• Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding., Glycobiology, 14(2), 103-14, 2004
  Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MR
• Human Skin Cancers: Pathways, Mechanisms, Targets and Treatments in The Multiple Roles of Tyrosinase-Related Protein-2/LDopachrome Tautomerase in Melanoma: Biomarker, Therapeutic Target, and Molecular Driver in Tumor Progression(3), IntechOpen, 22-33, 2018
  Adina L. Milac, Gabriela Negroiu

Grants