Adina-Luminita Milac, Ph.D habil

Biography

Papers

• Famiglietti AL, Wei Z, Beres TM, Milac AL, Tran DT, Patel D, Angerer RC, Angerer LM, Tabak LAFamiglietti AL et al . Characterization and expression analysis of Galnts in developing Strongylocentrotus purpuratus embryos. PloS one, 2017, 12(4):e0176479.IF=2.77
• Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu GPopa IL et al . Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression. The Journal of biological chemistry, 2016, 291(24):12481-500.IF=4.12
• Avram S, Borcan F, Borcan LC, Milac AL, Mihailescu DAvram S et al . QSAR Approaches Applied to Antidepressants Induced Neurogenesis--in vivo and in silico Applications. Mini reviews in medicinal chemistry, 2015, 16(3):230-40.
• Avram S, Milac A, Mernea M, Mihailescu D, Putz MV, Buiu CAvram S et al . Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control. International journal of molecular sciences, 2014, 15(11):21381-400.
• Milac AL, Bojarska E, Wypijewska del Nogal AMilac AL et al . Decapping Scavenger (DcpS) enzyme: advances in its structure, activity and roles in the cap-dependent mRNA metabolism. Biochimica et biophysica acta, 2014, 1839(6):452-62.
• Filimon A, Zurac SA, Milac AL, Sima LE, Petrescu SM, Negroiu GFilimon A et al . Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. Melanoma research, 2014, 24(3):219-36.
• Wypijewska del Nogal A, Surleac MD, Kowalska J, Lukaszewicz M, Jemielity J, Bisaillon M, Darzynkiewicz E, Milac AL, Bojarska EWypijewska del Nogal A et al . Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding. The FEBS journal, 2013, 280(24):6508-27.IF=3.99
• Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita NFlorian PE et al . Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide. Journal of medical virology, 2013, 85(5):780-8.IF=2.22
• Avram S, Milac AL, Carta F, Supuran CTAvram S et al . More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design. Journal of enzyme inhibition and medicinal chemistry, 2013, 28(2):350-9.
• Avram S, Milac AL, Mihailescu DAvram S et al . 3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A. Molecular bioSystems, 2012, 8(5):1418-25.IF=3.35
• Avram S, Buiu C, Borcan F, Milac ALAvram S et al . More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis. Molecular bioSystems, 2012, 8(2):587-94.
• Milac A, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HRMilac A et al . Structural models of TREK channels and their gating mechanism. Channels (Austin, Tex.), 2011, 5(1):23-33.
• Maksaev G, Milac A, Anishkin A, Guy HR, Sukharev SMaksaev G et al . Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models. Channels (Austin, Tex.), 2011, 5(1):34-42.
• Anishkin A, Milac AL, Guy HRAnishkin A et al . Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels. Proteins, 2010, 78(4):932-49.
• Kudla U, Milac AL, Qin L, Overmars H, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant GKudla U et al . Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis. Molecular plant pathology, 2007, 8(3):293-305.
• Milac AL, Buchete NV, Fritz TA, Hummer G, Tabak LAMilac AL et al . Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2. Journal of molecular biology, 2007, 373(2):439-51.
• Milac AL, Avram S, Petrescu AJMilac AL et al . Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors. Application to HIV-1 protease inhibitors. Journal of molecular graphics & modelling, 2006, 25(1):37-45.
• Jaubert S, Milac AL, Petrescu AJ, de Almeida-Engler J, Abad P, Rosso MNJaubert S et al . In planta secretion of a calreticulin by migratory and sedentary stages of root-knot nematode. Molecular plant-microbe interactions : MPMI, 2005, 18(12):1277-84.
• Costin GE, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Vieira WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJCostin GE et al . Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein. The Biochemical journal, 2005, 391(Pt 2):249-59.
• Kudla U, Qin L, Milac A, Kielak A, Maissen C, Overmars H, Popeijus H, Roze E, Petrescu A, Smant G, Bakker J, Helder JKudla U et al . Origin, distribution and 3D-modeling of Gr-EXPB1, an expansin from the potato cyst nematode Globodera rostochiensis. FEBS letters, 2005, 579(11):2451-7.
• Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MRPetrescu AJ et al . Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding. Glycobiology, 2004, 14(2):103-14.
• Adina L. Milac, Gabriela Negroiu. Human Skin Cancers: Pathways, Mechanisms, Targets and Treatments in The Multiple Roles of Tyrosinase-Related Protein-2/LDopachrome Tautomerase in Melanoma: Biomarker, Therapeutic Target, and Molecular Driver in Tumor Progression, 2018(3), IntechOpen:22-33.
• Surleac MD, Spiridon LN, TacutuR, Milac AL, Petrescu SM, Petrescu AJSurleac MD et al . Glycosilation in Structural Assessment of Glycosylation Sites Database - SAGS – An Overall View on N-Glycosylation, 2012(1), InTech:3-20.

Grants