Cristina Stefana Orobeti, MSc
2017-present: Master student at Smart Biomaterials and Applications Programme, Faculty of Medical Engineering, Polytechnic University of Bucharest Romania.
2016-present: Research assistant at Center for Advanced Laser Technologies Department, National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Romania.
2018-present: Research assistant at Molecular Cell Biology Department, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.
The overall goal of the current project is to understand the impact of tissue transglutaminase (TG2) targeting in the context of ovarian cancer (OC) tumor microenvironment (TME). Our aproach is aimed at testing the hypothesis that interventions in targeting TG2 in the OC TME will disrupt pro-tumorigenic signaling cross-talk within tumors.
The principal goal of this project is the development of a new class of small molecule inhibitors (SMIs) targeting TG2-FN interaction, which is currently in the phase of lead optimization, translatable to clinical use for prevention of ovarian cancer dissemination, either alone or in combinations.