Hepatitis B (HBV) and C viruses (HCV) are important human pathogens resulting in more than 500 million people being currently carriers. Sadly, Romania has the highest prevalence of HBV/HCV infections among the EU countries (up to 7% of the population). Chronically infected patients of HBV and HCV are at high risk to develop severe liver diseases, such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).
Hepatitis B (HBV) and C viruses (HCV) are important human pathogens resulting in more than 500 million people being currently carriers. Sadly, Romania has the highest prevalence of HBV/HCV infections among the EU countries (up to 7% of the population). Chronically infected patients of HBV and HCV are at high risk to develop severe liver diseases, such as fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Current therapies against HBV/HCV, based on replication inhibitors and immune system activators are associated with severe side effects. Moreover, both viruses are prone to development of resistance to antiviral inhibitors. The objective of this project is to contribute to sustainable improvements in health of vulnerable social groups in Romania through bilateral collaboration of Romania and Norway with international partners participation.
The outcomes are:
The overall objective of this GreenVac research project is to contribute to sustainable improvements in health of vulnerable social groups in Romania, in accordance with the health-related millennium development goals (MDGs) of the United Nation. It is also highly relevant to the EEA Research Programme between Romania and Norway where health is one of the four prioritized thematic areas.
Our specific objectives for this Romanian -Norwegian bilateral project on: "Developing a cost effective Romania-Norway joint plant-based technology platform for production of oral and intravenous vaccines against Hepatitis viruses HCV and HBV" are:
However, edible crops offer unique advantages in significantly reducing these costs. We take thus our experience in tobacco produced vaccine development a key step forward by aiming to:
Capacity building by recruiting a PhD student in Romania and dissemination of our knowledge and project results are also important for the project. In addition to Norway and Romania, the project consortium includes also experienced European scientists from leading institutions in Germany and France. The platform we establish during this project will facilitate our collaboration in the future.
Following outcomes can be expected from this project:
Dr. Norica Nichita was invited to Radio Romania Cultural, as a special guest of the show "Science in appropriate words", on November 10, 2016.
"GREENVAC" project was advertised during the Joint Meetings: "8-th National HIV/AIDS Congress" and "3rd Central European HIV Forum", May 5-7, 2016, Sibiu, Romania
PROJECT PROMOTER - The Instiute of Biochemistry of the Romanian Academy
|Project Coordinator||Dr. Norica Nichita|
|Team Member||Dr. biochim Lazar|
|Team Member||Dr. Ionut Popescu|
|Team Member||Res. Assist. biochima Petrareanu|
|Team Member||Res. Assist. Olivia Dobrica|
PARTNER 1 - The Norwegian Institute for Agricultural & Environmental Research Bioforsk
|Team Leader||Dr. Jihong Liu Clarke|
|Team Member||Dr. Lisa Paruch|
|Team Member||Dr. Stefanox Xenarios|
|Team Member||Prof. Ralph Bock|
PARTNER 2 - The "Cantacuzino" National Institute for Research and Development for Microbiology and Immunology
|Team Leader||Dr. Crina Stavaru|
|Team Member||Dr. Adrian Onu|
|Team Member||Dr. Iuliana Caras|
|Team Member||Dr. Adina Iancu|
|Team Member||Dr. Adriana Costache|
|Team Member||Ene Vlase (DVM)|
|Team Member||Res. Assist. biochim Tucureanu|
|Team Member||Tech. Assist. Viorica Andras|
|Team Member||Tech. Assist. Daniela Florescu|
|Team Member||Tech. Assist. Doina Preoteasa|
PARTNER 3 - The National Institute for Infectious Diseases "Matei Bals"
|Team Leader||Dr. Dan Otelea|
|Team Member||Dr. Simona Paraschiv|
|Team Member||Dr. Leontina Banica|
|Team Member||Dr. Valeriu Gheorghita|
|Team Member||Tech. Assist. Dana Ioan|
Center for Infection and Immunity of Lille
|Team Leader||Dr. Jean Dubuisson|